Document Type : Original Article- Persian
Authors
1
MSc of Microbiology, Department of Microbiology, Faculty of Advanced Science and Technology, TMS.C., Islamic Azad University, Tehran, Iran.
2
Assistant Professor of Microbiology, Department of Microbiology, Faculty of Medicine, TMS.C., Islamic Azad University, Tehran, Iran.
3
Assistant Professor of Immunology, Department of Immunology, Faculty of Medicine, TMS.C., Islamic Azad University, Tehran, Iran.
4
Assistant Professor of Immunology, Immunology research center, institute of immunology and infectious diseases, Iran university of medical sciences, Tehran, Iran.
5
Institute of immunology & Infectious disease
10.22108/bjm.2026.148403.1669
Abstract
Introduction: At present, antibiotic resistance is recognized as one of the major global threats to human health. The clinical importance of Acinetobacter baumannii (A. baumannii) is due to its ability to acquire and transmit antibiotic resistance factors. Resistance genes, such as class D β-lactamases (oxacillinases), enable A. baumannii to resist the action of several antibiotic families.
The aim of this study was to monitor the antibiotic resistance pattern and to estimate the prevalence of the resistance genes blaOXA-23 and blaOXA-51 in Acinetobacter baumannii isolates obtained from hospitalized patients in a hospital in Tehran Province.
Materials and Methods: In this study, 60 Acinetobacter baumannii isolates were collected from hospitalized patients in a teaching hospital in Tehran Province in 2024. After performing biochemical tests for final bacterial identification, the antibiotic susceptibility of isolates against 12 antibiotics was determined using the agar disk diffusion method. Colistin susceptibility was also evaluated using a disk diffusion method. Then, the prevalence of antibiotic resistance genes blaOXA-23 and blaOXA-51 was assessed by PCR.
Results: In this study, among 60 isolates, the highest observed susceptibility was to colistin with 3.3% resistance, while the highest resistance (100%) was to imipenem, cefepime, cefotaxime, piperacillin–tazobactam, and ciprofloxacin. The prevalence of blaOXA-23 and blaOXA-51 was 81.6% and 100%, respectively.
Conclusion: The increase in antibiotic resistance and widespread prevalence of resistance genes have caused serious concerns. Effective infection control and prevention of the spread of drug-resistant bacteria require precise drug prescription management and timely identification of resistant isolates.
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